Design, Synthesis and Evaluation of 6-Oxo-1, 6-dihydropyrimidine-2, 5-dicarboxamide Derivatives as MMP 13 Inhibitors

doi:10.1007/s40242-012-2131-2

高等学校化学研究 ›› 2013, Vol. 29 ›› Issue (1): 67-70.doi: 10.1007/s40242-012-2131-2

Design, Synthesis and Evaluation of 6-Oxo-1, 6-dihydropyrimidine-2, 5-dicarboxamide Derivatives as MMP 13 Inhibitors

LU Hai-bin¹, WANG Shi-han¹, LI Qing-min¹, WANG Yong-sheng^1,2

1. College of Pharmacy, Jilin University, Changchun 130021, P. R. China;
2. Changchun University of Chinese Medicine, Changchun 130021, P. R. China

收稿日期:2012-04-01 修回日期:2012-05-10 出版日期:2013-02-01 发布日期:2013-01-23
基金资助:
Supported by the Innovative Projects of Young Teacher of Jilin University, China(No.450060441137).

Design, Synthesis and Evaluation of 6-Oxo-1, 6-dihydropyrimidine-2, 5-dicarboxamide Derivatives as MMP 13 Inhibitors

LU Hai-bin¹, WANG Shi-han¹, LI Qing-min¹, WANG Yong-sheng^1,2

1. College of Pharmacy, Jilin University, Changchun 130021, P. R. China;
2. Changchun University of Chinese Medicine, Changchun 130021, P. R. China

Received:2012-04-01 Revised:2012-05-10 Online:2013-02-01 Published:2013-01-23
Supported by:
Supported by the Innovative Projects of Young Teacher of Jilin University, China(No.450060441137).

摘要/Abstract

摘要：

We designed and synthsized a series of novel 6-oxo-1,6-dihydropyrimidine-2,5-dicarboxamide derivatives and evaluated their inhibition effects on MMP 3, MMP 12 and MMP 13. The pharmacological results show that they have potent and highly selective activity of inhibiting MMP 13.

关键词: Matrix metalloproteinase 13(MMP 13), Matrix metalloproteinase(MMP), Inhibition

Abstract:

Key words: Matrix metalloproteinase 13(MMP 13), Matrix metalloproteinase(MMP), Inhibition

LU Hai-bin, WANG Shi-han, LI Qing-min, WANG Yong-sheng. Design, Synthesis and Evaluation of 6-Oxo-1, 6-dihydropyrimidine-2, 5-dicarboxamide Derivatives as MMP 13 Inhibitors[J]. 高等学校化学研究, 2013, 29(1): 67-70.

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Design, Synthesis and Evaluation of 6-Oxo-1, 6-dihydropyrimidine-2, 5-dicarboxamide Derivatives as MMP 13 Inhibitors

Design, Synthesis and Evaluation of 6-Oxo-1, 6-dihydropyrimidine-2, 5-dicarboxamide Derivatives as MMP 13 Inhibitors

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