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高等学校化学研究 ›› 2012, Vol. 28 ›› Issue (5): 837-842 .

• Articles • 上一篇    下一篇

Synthesis, Crystal Structure and Biological Activites of Rotenone O-Alkyl Oximes

CHEN Xiao-dong, WANG Chao, HU Ai-xi, YE Jiao, ZHANG Cui-yang   

  1. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
  • 收稿日期:2011-11-08 修回日期:2011-12-21 出版日期:2012-09-25 发布日期:2012-09-07
  • 通讯作者: HU Ai-xi E-mail:axhu@hnu.edu.cn
  • 基金资助:
    Supported by the National Science and Technology Pillar Program of China(No.2011BAE06B01).

Synthesis, Crystal Structure and Biological Activites of Rotenone O-Alkyl Oximes

CHEN Xiao-dong, WANG Chao, HU Ai-xi, YE Jiao, ZHANG Cui-yang   

  1. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
  • Received:2011-11-08 Revised:2011-12-21 Online:2012-09-25 Published:2012-09-07
  • Supported by:
    Supported by the National Science and Technology Pillar Program of China(No.2011BAE06B01).

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摘要： A series of rotenone O-alkyl oxime derivatives was designed and synthesized. Their structures were confirmed by elemental analyses, Fourier transform infrared(FTIR) and 1H NMR spectral studies, and the typical crystal structure of rotenone O-ethyl oxime(3b) was determined by X-ray diffraction. The preliminary biological activities of the new compounds were evaluated. The results of bioassays indicate that the title compounds exhibit moderate insecticidal and bactericidal activities. Among the synthesized compounds, compound 3q exhibited 90.0% mortality against M. separata at 1000 μg/mL. Compounds 3b and 3g exhibited both 90.0% inhibition rate against R. solani at 500 μg/mL, respectively.

关键词: Rotenone O-alkyl oxime, Crystal structure of rotenone O-ethyl oxime, Biological activity

Abstract: A series of rotenone O-alkyl oxime derivatives was designed and synthesized. Their structures were confirmed by elemental analyses, Fourier transform infrared(FTIR) and 1H NMR spectral studies, and the typical crystal structure of rotenone O-ethyl oxime(3b) was determined by X-ray diffraction. The preliminary biological activities of the new compounds were evaluated. The results of bioassays indicate that the title compounds exhibit moderate insecticidal and bactericidal activities. Among the synthesized compounds, compound 3q exhibited 90.0% mortality against M. separata at 1000 μg/mL. Compounds 3b and 3g exhibited both 90.0% inhibition rate against R. solani at 500 μg/mL, respectively.

Key words: Rotenone O-alkyl oxime, Crystal structure of rotenone O-ethyl oxime, Biological activity