Chitosan-graft-poly(L-glutamic acid) Hybrid Material and Its Self-assembly

高等学校化学研究 ›› 2012, Vol. 28 ›› Issue (5): 921-925 .

Chitosan-graft-poly(L-glutamic acid) Hybrid Material and Its Self-assembly

LIU Ye-zhuo, YAO Jin-rong, CAO Heng, LENG Bo-xun, SHAO Zheng-zhong, CHEN Xin

State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials,Department of Macromolecular Science, Fudan University, Shanghai 200433, P. R. China

收稿日期:2011-10-17 修回日期:2011-12-19 出版日期:2012-09-25 发布日期:2012-09-07
通讯作者: YAO Jin-rong, CHEN Xin E-mail:chenx@fudan.edu.cn; yaoyaojr@fudan.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China(Nos.21034003, 20974025, 10979022).

Chitosan-graft-poly(L-glutamic acid) Hybrid Material and Its Self-assembly

LIU Ye-zhuo, YAO Jin-rong, CAO Heng, LENG Bo-xun, SHAO Zheng-zhong, CHEN Xin

State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials,Department of Macromolecular Science, Fudan University, Shanghai 200433, P. R. China

Received:2011-10-17 Revised:2011-12-19 Online:2012-09-25 Published:2012-09-07
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21034003, 20974025, 10979022).

摘要/Abstract

摘要： Chitosan-graft-poly(L-glutamic acid)(CS-g-PGA) copolymer was successfully synthesized by grafting polymerization of γ-benzyl-L-glutamate N-carboxyanhydride onto the modified chitosan chains. The self-assembly behavior of such a CS-g-PGA amphiphilic copolymer was studied. The results show that spherical nanoparticles have been formed. The size of CS-g-PGA nanoparticles is found to be controlled by the grafting ratio of PGA. These bio-based polysaccharide/polypeptide hybrid nanoparticles with controllable size may have great potential application in biomedical fields, such as drug delivery systems.

关键词: Biopolymer, Nanoparticle, Graft copolymer, Self-assembly

Abstract: Chitosan-graft-poly(L-glutamic acid)(CS-g-PGA) copolymer was successfully synthesized by grafting polymerization of γ-benzyl-L-glutamate N-carboxyanhydride onto the modified chitosan chains. The self-assembly behavior of such a CS-g-PGA amphiphilic copolymer was studied. The results show that spherical nanoparticles have been formed. The size of CS-g-PGA nanoparticles is found to be controlled by the grafting ratio of PGA. These bio-based polysaccharide/polypeptide hybrid nanoparticles with controllable size may have great potential application in biomedical fields, such as drug delivery systems.

Key words: Biopolymer, Nanoparticle, Graft copolymer, Self-assembly

LIU Ye-zhuo, YAO Jin-rong, CAO Heng, LENG Bo-xun, SHAO Zheng-zhong, CHEN Xin. Chitosan-graft-poly(L-glutamic acid) Hybrid Material and Its Self-assembly[J]. 高等学校化学研究, 2012, 28(5): 921-925 .

LIU Ye-zhuo, YAO Jin-rong, CAO Heng, LENG Bo-xun, SHAO Zheng-zhong, CHEN Xin. Chitosan-graft-poly(L-glutamic acid) Hybrid Material and Its Self-assembly[J]. Chemical Research in Chinese Universities, 2012, 28(5): 921-925 .

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Chitosan-graft-poly(L-glutamic acid) Hybrid Material and Its Self-assembly

Chitosan-graft-poly(L-glutamic acid) Hybrid Material and Its Self-assembly

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