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高等学校化学研究 ›› 1997, Vol. 13 ›› Issue (4): 336-343.

• Articles • 上一篇    下一篇

Studies on Hepatocyte-Targeting Magnetic Resonance Imaging Macromolecular Contrast Media

FU Yan-jun, ZHUO Ren-xi   

  1. Department of Chemistry, Wuhan University, Laboratory of Biomedical Polymer Materials of the State Education Commission of China, Wuhan 430072
  • 收稿日期:1996-09-04 出版日期:1997-12-24 发布日期:2011-08-17
  • 基金资助:

    Supported by the Foundation of the State Education Commission of China.

Studies on Hepatocyte-Targeting Magnetic Resonance Imaging Macromolecular Contrast Media

FU Yan-jun, ZHUO Ren-xi   

  1. Department of Chemistry, Wuhan University, Laboratory of Biomedical Polymer Materials of the State Education Commission of China, Wuhan 430072
  • Received:1996-09-04 Online:1997-12-24 Published:2011-08-17
  • Supported by:

    Supported by the Foundation of the State Education Commission of China.

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摘要： DTPA was covalently conjugated to the copolymer of L-lysine and L-tyrosine, then transchelated with Gd-EDTA,the resultant polymer chelates were further reacted with 6-O-bromoacety-l-D-galactose or methyl lactobionyloxyacetate to give PLT(Gd-DTPA) with galactose moiety as liver- targeting group.These macromolecular MRI contrast agents were characterized by means of FT-IR, ICP-AES, elementary analyses and UV-Vis spectrophotometry. Their in vitro relaxivity and liver targeting property in mice were also investigated.

关键词: MRI macromolecular contrast media(MMCM), Polylysine, Hepatocyte-targeting, Relaxivity, Biodistribution

Abstract: DTPA was covalently conjugated to the copolymer of L-lysine and L-tyrosine, then transchelated with Gd-EDTA,the resultant polymer chelates were further reacted with 6-O-bromoacety-l-D-galactose or methyl lactobionyloxyacetate to give PLT(Gd-DTPA) with galactose moiety as liver- targeting group.These macromolecular MRI contrast agents were characterized by means of FT-IR, ICP-AES, elementary analyses and UV-Vis spectrophotometry. Their in vitro relaxivity and liver targeting property in mice were also investigated.

Key words: MRI macromolecular contrast media(MMCM), Polylysine, Hepatocyte-targeting, Relaxivity, Biodistribution