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高等学校化学研究 ›› 1993, Vol. 9 ›› Issue (4): 303-308.

• Articles • 上一篇    下一篇

Mixed Binder Carbon Paste Electrode for Quantitation of Isoniazid in Serum

ZHANG Zheng-Qi, CHEN Sheng-Zong, LI Ning-Huai, ZHANG Hong   

  1. Department of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082
  • 收稿日期:1993-01-20 出版日期:1993-12-24 发布日期:2011-08-17

Mixed Binder Carbon Paste Electrode for Quantitation of Isoniazid in Serum

ZHANG Zheng-Qi, CHEN Sheng-Zong, LI Ning-Huai, ZHANG Hong   

  1. Department of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082
  • Received:1993-01-20 Online:1993-12-24 Published:2011-08-17

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被引次数

3

摘要： This paper covers the construction and behaviour of a mixed binder carbon paste electrode system appropriate for the cathodic stripping voltammetric quantitation of iso-niazid. The mixed binder consisted of glycerol and liquid paraffin. At the mixed binder carbon paste electrodes in a pH 3.0 buffer solution, isoniazid showed two sensitive cathodic stripping voltammetric wave at-0. 75 V (p1) and-0. 88 V (p2), respectively. The p2 can be used for the determination of trace amounts of isoniazid, the linear range of the peak current to the isoniazid concentration being from 5. 0×10-7 to 5.0×10-5 mol/L, and the limit of detection being 1. 0×10-7 mol/L with a relative standard deviation of 6. 0%(n=10). The proposed method was directly used to determine the drug in blood serum without the pretreatment of blood serum.

关键词: Carbon paste electrode, Isoniazid, Stripping voltammetry

Abstract: This paper covers the construction and behaviour of a mixed binder carbon paste electrode system appropriate for the cathodic stripping voltammetric quantitation of iso-niazid. The mixed binder consisted of glycerol and liquid paraffin. At the mixed binder carbon paste electrodes in a pH 3.0 buffer solution, isoniazid showed two sensitive cathodic stripping voltammetric wave at-0. 75 V (p1) and-0. 88 V (p2), respectively. The p2 can be used for the determination of trace amounts of isoniazid, the linear range of the peak current to the isoniazid concentration being from 5. 0×10-7 to 5.0×10-5 mol/L, and the limit of detection being 1. 0×10-7 mol/L with a relative standard deviation of 6. 0%(n=10). The proposed method was directly used to determine the drug in blood serum without the pretreatment of blood serum.

Key words: Carbon paste electrode, Isoniazid, Stripping voltammetry