Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study

高等学校化学研究 ›› 2012, Vol. 28 ›› Issue (1): 166-170.

• Articles • 上一篇

Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study

JI Jin-gou*, ZHANG Jing-fen, HAO Shi-lei, WU Dan-jun, LIU Li, XU Yi

College of Chemistry and Chemical Engineering, University of Chongqing, Chongqing 400030, P. R. China

收稿日期:2011-01-13 修回日期:2011-07-08 出版日期:2012-01-25 发布日期:2011-12-27
基金资助:
Supported by the Key Scientific and Technological Projects of Chongqing Science and Technology Commission, China (No.CSTC2010AC5050) and the Chongqing University(China) Postgraduates' Science and Innovation Fund (No.CDJXS10220008).

Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study

JI Jin-gou*, ZHANG Jing-fen, HAO Shi-lei, WU Dan-jun, LIU Li, XU Yi

College of Chemistry and Chemical Engineering, University of Chongqing, Chongqing 400030, P. R. China

Received:2011-01-13 Revised:2011-07-08 Online:2012-01-25 Published:2011-12-27
Contact: Jin-gou E-mail:jingou_ji@yahoo.com.cn
Supported by:
Supported by the Key Scientific and Technological Projects of Chongqing Science and Technology Commission, China (No.CSTC2010AC5050) and the Chongqing University(China) Postgraduates' Science and Innovation Fund (No.CDJXS10220008).

摘要/Abstract

摘要： Chitosan/cyclodextrin/trisodium citrate(CS/CD/TSC) nanoparticles with ibuprofen(IBU) loaded were prepared via the ionic cross-linking method, with trisodium citrate selected as the cross-linking agent. The drug-loading capacity, particle size, zeta potential and surface morphology of the obtained nanoparticles were investigated. The results show a good drug-loading capacity. The prepared nanoparticles were spherical in shape with an average size of 293.7 nm and a zeta potential of +30.72 mV. The in vitro release studies show that the controlled release of IBU from the nanoparticles was followed. The drug release from CS/β-CD/TSC nanoparticles followed non-Fickian or anomalous diffusion.

关键词: Chitosan, Cyclodextrin, Nanoparticle, Ibuprofen(IBU)

Abstract: Chitosan/cyclodextrin/trisodium citrate(CS/CD/TSC) nanoparticles with ibuprofen(IBU) loaded were prepared via the ionic cross-linking method, with trisodium citrate selected as the cross-linking agent. The drug-loading capacity, particle size, zeta potential and surface morphology of the obtained nanoparticles were investigated. The results show a good drug-loading capacity. The prepared nanoparticles were spherical in shape with an average size of 293.7 nm and a zeta potential of +30.72 mV. The in vitro release studies show that the controlled release of IBU from the nanoparticles was followed. The drug release from CS/β-CD/TSC nanoparticles followed non-Fickian or anomalous diffusion.

Key words: Chitosan, Cyclodextrin, Nanoparticle, Ibuprofen(IBU)

JI Jin-gou, ZHANG Jing-fen, HAO Shi-lei, WU Dan-jun, LIU Li, XU Yi. Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study[J]. 高等学校化学研究, 2012, 28(1): 166-170.

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Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study

Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study

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