Tetra-n-butylammonium Hydroxide: an Efficient Catalyst for N-Alkylation of Pyrimidines and Purines

高等学校化学研究 ›› 2006, Vol. 22 ›› Issue (4): 451-454.

Tetra-n-butylammonium Hydroxide: an Efficient Catalyst for N-Alkylation of Pyrimidines and Purines

ZHANG Zhi-li, ZHOU Shou-xin, WANG Xiao-wei, WANG Hong-tao, CHEN Yan-li, LIU Jun-yi

Department of Chemical Biology,School of Pharmaceutical Sciences;State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P. R. China

收稿日期:2005-06-14 出版日期:2006-08-24 发布日期:2011-08-06
基金资助:
Supported by the National Natural Science Foundation of China(No. 20172007) and the "985" Programs, Ministry of Education of China.

Tetra-n-butylammonium Hydroxide: an Efficient Catalyst for N-Alkylation of Pyrimidines and Purines

ZHANG Zhi-li, ZHOU Shou-xin, WANG Xiao-wei, WANG Hong-tao, CHEN Yan-li, LIU Jun-yi

Department of Chemical Biology,School of Pharmaceutical Sciences;State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, P. R. China

Received:2005-06-14 Online:2006-08-24 Published:2011-08-06
Supported by:
Supported by the National Natural Science Foundation of China(No. 20172007) and the "985" Programs, Ministry of Education of China.

摘要/Abstract

摘要： An efficient procedure for N-alkylation of pyrimidines and purines in the presence of tetra-n-butylammonium hydroxide(TBAH) is described. The method is very practical and the alkylation can occur at room temperature and the yields of the N-alkyl pyrimidines and purines were found to be excellent.

关键词: Tetra-n-butylammonium hydroxide, N-Alkylation, Purine, Pyrimidine

Abstract: An efficient procedure for N-alkylation of pyrimidines and purines in the presence of tetra-n-butylammonium hydroxide(TBAH) is described. The method is very practical and the alkylation can occur at room temperature and the yields of the N-alkyl pyrimidines and purines were found to be excellent.

Key words: Tetra-n-butylammonium hydroxide, N-Alkylation, Purine, Pyrimidine

ZHANG Zhi-li, ZHOU Shou-xin, WANG Xiao-wei, WANG Hong-tao, CHEN Yan-li, LIU Jun-yi. Tetra-n-butylammonium Hydroxide: an Efficient Catalyst for N-Alkylation of Pyrimidines and Purines[J]. 高等学校化学研究, 2006, 22(4): 451-454.

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Tetra-n-butylammonium Hydroxide: an Efficient Catalyst for N-Alkylation of Pyrimidines and Purines

Tetra-n-butylammonium Hydroxide: an Efficient Catalyst for N-Alkylation of Pyrimidines and Purines

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