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高等学校化学研究 ›› 2002, Vol. 18 ›› Issue (2): 146-152.

• Articles • 上一篇    下一篇

Facile Syntheses of (6S)-6-Fluoroshikimic Acid and (6R)-6-Hydroxyshikimic Acid

Chuanjun Song1,2, Shende Jiang1, Gurdial Singh1   

  1. 1. Department of Chemistry, University of Sunderland, Sunderland, SR1 3SD, UK;
    2. Department of Applied Chemistry, Tianjin University, Tianjin 300072, P. R. China
  • 收稿日期:2001-12-12 出版日期:2002-04-24 发布日期:2011-08-04

Facile Syntheses of (6S)-6-Fluoroshikimic Acid and (6R)-6-Hydroxyshikimic Acid

Chuanjun Song1,2, Shende Jiang1, Gurdial Singh1   

  1. 1. Department of Chemistry, University of Sunderland, Sunderland, SR1 3SD, UK;
    2. Department of Applied Chemistry, Tianjin University, Tianjin 300072, P. R. China
  • Received:2001-12-12 Online:2002-04-24 Published:2011-08-04

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摘要： (6S)-6-Fluoroshikimic acid 2 and (6R)-6-hydroxyshikimic acid 3 have been synthesized via an OsO4-catal-ysed dihydroxylation of diene 7, which was derived from (-)-shikimic acid 1.

关键词: Shikimate pathway, Shikimic acid, Fluoroshikimic acid, Dihydroxylation, Fluorination

Abstract: (6S)-6-Fluoroshikimic acid 2 and (6R)-6-hydroxyshikimic acid 3 have been synthesized via an OsO4-catal-ysed dihydroxylation of diene 7, which was derived from (-)-shikimic acid 1.

Key words: Shikimate pathway, Shikimic acid, Fluoroshikimic acid, Dihydroxylation, Fluorination