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高等学校化学研究 ›› 2005, Vol. 21 ›› Issue (6): 692-696.

• Articles • 上一篇    下一篇

Effect Factors in Synthesis of Nicotinic Acid by Electrooxidation of 3-Picoline

SUN Xiu-yun1,2, ZHANG Yu-min1, CAO Xue-jing1, ZHANG Heng-bin1, LI Fei1, XU Yu-ling1   

  1. 1. College of Chemistry, Jilin University, Changchun 130021, P. R. China;
    2. Department of Applied Chemistry, Jilin Institute of Chemical Technology, Jilin 132022, P. R. China
  • 收稿日期:2004-11-30 出版日期:2005-11-23 发布日期:2011-08-06
  • 基金资助:

    Supported by the National Natural Science Foundation of China (No.20373020) and the Natural Science Foundation of Jilin Province(No.20020643-2)

Effect Factors in Synthesis of Nicotinic Acid by Electrooxidation of 3-Picoline

SUN Xiu-yun1,2, ZHANG Yu-min1, CAO Xue-jing1, ZHANG Heng-bin1, LI Fei1, XU Yu-ling1   

  1. 1. College of Chemistry, Jilin University, Changchun 130021, P. R. China;
    2. Department of Applied Chemistry, Jilin Institute of Chemical Technology, Jilin 132022, P. R. China
  • Received:2004-11-30 Online:2005-11-23 Published:2011-08-06
  • Supported by:

    Supported by the National Natural Science Foundation of China (No.20373020) and the Natural Science Foundation of Jilin Province(No.20020643-2)

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被引次数

4

摘要： In an electrolytic cell with a proton exchange membrane, nicotinic acid was synthesized at the PbO2 anode.The relationship between the current density and the potential at different concentrations of 3-picoline and sulfuric acid as well as at different temperatures was studied with polarization curves.The effects of the concentrations of sulfuric acid and 3-picoline, the anode potential and the reaction temperature on the selectivity and the current efficiency were explored.The optimum conditions were determined by orthogonal experiments.Under optimum conditions the selectivity and the current efficiency for the synthesis of nicotinic acid might reach 89% and 65%, respectively.The concentrations of 3-picoline and nicotinic acid were analyzed with high performance liquid chromatography and the product was characterized with elemental analysis, chromatography-mass spectrometry and IR spectrometry.

关键词: 3-Picoline, Nicotinic acid, Electrooxidation, Electroorganic synthesis

Abstract: In an electrolytic cell with a proton exchange membrane, nicotinic acid was synthesized at the PbO2 anode.The relationship between the current density and the potential at different concentrations of 3-picoline and sulfuric acid as well as at different temperatures was studied with polarization curves.The effects of the concentrations of sulfuric acid and 3-picoline, the anode potential and the reaction temperature on the selectivity and the current efficiency were explored.The optimum conditions were determined by orthogonal experiments.Under optimum conditions the selectivity and the current efficiency for the synthesis of nicotinic acid might reach 89% and 65%, respectively.The concentrations of 3-picoline and nicotinic acid were analyzed with high performance liquid chromatography and the product was characterized with elemental analysis, chromatography-mass spectrometry and IR spectrometry.

Key words: 3-Picoline, Nicotinic acid, Electrooxidation, Electroorganic synthesis